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Paleopathology of human tuberculosis and the potential role of climate

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dc.contributor.author Nerlich, Andreas G.
dc.contributor.author Lösch, Sandra
dc.date.accessioned 2014-11-27T06:39:01Z
dc.date.available 2014-11-27T06:39:01Z
dc.date.issued 2009-01-27
dc.identifier.citation Nerlich, A. G. & Lösch, S. (2009). Paleopathology of human tuberculosis and the potential role of climate. Interdisciplinary perspectives on infectious diseases, Article ID 437187. en_GB
dc.identifier.other DOI: 10.1155/2009/437187
dc.identifier.uri http://www.taccire.sua.ac.tz/handle/123456789/314
dc.description This article is available at http://dx.doi.org/10.1155/2009/437187 en_GB
dc.description.abstract Both origin and evolution of tuberculosis and its pathogens (Mycobacterium tuberculosis complex) are not fully understood. The paleopathological investigation of human remains offers a unique insight into the molecular evolution and spread including correlative data of the environment. Themolecular analysis of material from Egypt (3000–500 BC), Sudan (200–600 AD),Hungary (600–1700 AD), Latvia (1200–1600 AD), and South Germany (1400–1800 AD) surprisingly revealed constantly high frequencies of tuberculosis in all different time periods excluding significant environmental influence on tuberculosis spread. The typing of various mycobacteria strains provides evidence for ancestral M. tuberculosis strains in Pre- to early Egyptian dynastic material (3500–2650 BC), while typical M. africanum signatures were detected in a Middle Kingdom tomb (2050–1650 BC). Samples from the New Kingdom to Late Period (1500–500 BC) indicated modern M. tuberculosis strains. No evidence was seen for M. bovis in Egyptian material while M. bovis signatures were first identified in Siberian biomaterial dating 2000 years before present. These results contraindicates the theory that M. tuberculosis evolved from M. bovis during early domestication in the region of the “Fertile Crescent,” but supports the scenario that M. tuberculosis probably derived from an ancestral progenitor strain. The environmental influence of this evolutionary scenario deserves continuing intense evaluation. en_GB
dc.description.sponsorship The Deutsche Forschungsgemeinschaft (Grants NE 575/3-4 and NE 575/4-1). en_GB
dc.language.iso en en_GB
dc.publisher Hindawi Publishing Corporation en_GB
dc.subject Tuberculosis en_GB
dc.subject Climate change en_GB
dc.subject Environment en_GB
dc.subject Mycobacterium tuberculosis en_GB
dc.title Paleopathology of human tuberculosis and the potential role of climate en_GB
dc.type Article en_GB

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  • Climate Change impacts
    All information related to the effects and impacts of climate and weather variability --- be it on agriculture, environment, food security, transport, health etc

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